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The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

Virus StructureSignal TransductionMedicineReceptor Tyrosine KinaseHuman RetrovirusAntiviral ResponseMolecular BiologyUnexpected FoldHivBinding SurfaceHiv-1 NefCell SignalingStructural BiologyBiomolecular Engineering