Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC in the pulmonary artery adventitia

Abstract

PKCzeta acts as a replication repressor in Fib-C cells; however, the same isozyme mediates Fib-H proliferation. Thus, chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the PA adventitia.