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Prognostic markers in clinically localised prostate cancer.
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1999
Year
Tumor BiologyPrognostic BiomarkersUrologySurgical OncologyPerineural InvasionGenitourinary CancerMedicineTumour VolumeRadical ProstatectomyPathologyCancer PrognosisLocalised Prostate CancerBenign Prostatic HyperplasiaProstatic DiseaseGleason ScoreOncologyCancer Research
The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative margins with rising serum PSA (n=7), positive margins with stable serum PSA (n=7), positive margins with rising serum PSA (6) and patients with micrometastatic disease diagnosed in lymph nodes removed during radical prostatectomy (n=8). Gleason score and tumour volume were of prognostic significance and immunohistochemical staining for MIB-1 and BCL-2 showed added independent prognostic significance in multivariate analysis.