JNK/SAPK and p38 SAPK-2 Mediate Mechanical Stretch-Induced Apoptosis via Caspase-3 and -9 in NRK-52E Renal Epithelial Cells

Abstract

These findings suggest that stretch induces apoptosis in renal epithelial cells through the specific activation of JNK/SAPK and p38 SAPK-2 pathways and is dependent on the activation of caspase-3 and -9.