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Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes

Neurodegenerative DiseasesDifferent γ-Secretase ComplexesAlzheimer's DiseaseSynaptic SignalingDisease-associated Mutant PresenilinMolecular BiologyDegenerative PathologyPathological ActivityProtein MisfoldingNeurodegenerationBrain PathologyMedicineCell Biology