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Synthetic Approach to the Taxol Skeleton<sup>2</sup>
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1994
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EngineeringHeterocyclicBiochemistryAlkene MetathesisNatural SciencesUltrastructureMolecular BiologySynthetic ApproachOrganic ChemistryShort Synthetic RouteChemistryHeterocycle ChemistryChemical BiologyDiels-alder ReactionSynthetic ChemistryBiomolecular EngineeringAbc-ring Framework
A short synthetic route to the ABC-ring framework of taxol (1) has been developed by use of cyclic-azaallyl [4+3] cycloaddition, followed by Diels-Alder reaction and cyclopropanation.