Platelet-Rich Concentrate Supports Human Mesenchymal Stem Cell Proliferation, Bone Morphogenetic Protein-2 Messenger RNA Expression, Alkaline Phosphatase Activity, and Bone Formation In Vitro: A Mode of Action to Enhance Bone Repair

Abstract

Taken together, the data presented here suggest that treatment of hMSC with clotted PRC, in an osteoinductive environment, enhances osteoblastic commitment and bone formation. Furthermore, these data indicate that the enhanced osteogenesis seen in the presence of PRC cannot be explained solely by enhanced cell proliferation, suggesting that PRC modulates a number of cell and molecular pathways to promote bone formation.