Malignant Hypertension and Red Cell Fragmentation Syndrome

Abstract

Case Studies1 January 1966Malignant Hypertension and Red Cell Fragmentation SyndromeReport of a CaseJOHN P. CAPELLI, M.D., LAURENCE G. WESSON JR., M.D., F.A.C.P., ALLAN V. ERSLEV, M.D., F.A.C.P.JOHN P. CAPELLI, M.D., LAURENCE G. WESSON JR., M.D., F.A.C.P., ALLAN V. ERSLEV, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe almost invariable association of anemia with the uremic state has long been recognized (1-3), and although it is generally agreed that the major cause of anemia in chronic renal insufficiency is depression of erythropoiesis (4, 5), the mechanism remains unknown. It has been suggested that the uremia per se inhibits erythropoiesis (6, 7), but the failure of the kidney to supply an erythropoietic hormone has been considered of greater importance. The concentration of this hormone in the serum of patients with uremia and anemia is considerably less than in other states of anemia, and although it does not appear...References1. HUNTER W: An investigation into the pathology of pernicious anaemia. Lancet 2: 608, 1888. CrossrefGoogle Scholar2. QUINKE H: Zur pathologie des blutes. Deutsch. Arch. Klin. Med. 25: 567, 1880. Google Scholar3. WIDALABRAMIBRULE FPM: Anemie grave mortelle chez une brightique azotemique. Bull. Mem. Soc. Hop. Paris 24: 1427, 1907. Google Scholar4. DESFORGESDAWSON JFJP: The anemia of renal failure. Arch. Intern. Med. 101: 326, 1958. CrossrefGoogle Scholar5. LOGELANGEMOORE JPRDCV: Charterization of the anemia associated with chronic renal insufficiency. Amer. J. Med. 24: 4, 1958. CrossrefMedlineGoogle Scholar6. CALLENLIMARZI IRLR: Blood and bone marrow studies in renal disease. Amer. J. Clin. Path. 20: 3, 1950. CrossrefMedlineGoogle Scholar7. 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CAPELLI, M.D.; LAURENCE G. WESSONJR., M.D., F.A.C.P.; ALLAN V. ERSLEV, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Medicine and the Cardeza Foundation, Jefferson Medical College Hospital, Philadelphia, Pa.Requests for reprints should be addressed to John P. Capelli, M.D., Department of Medicine, Jefferson Medical College Hospital, 1025 Walnut St., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlterations in Blood ComponentsCase Report: Red Cell Fragmentation Produced by Renal Artery StenosisRecent Developments in the Anemia of Chronic Renal FailureHämatologische Aspekte arterieller HypertonieHematologic Aspects of Arterial HypertensionRed Cell Fragmentation in the Dog: An Editorial ReviewHypertensive emergenciesMicroangiopathic Hemolytic Anemia Associated with Radiation-Induced HemangiosarcomasHämatologische Aspekte arterieller HypertonieDie Klinik des h�molytisch-ur�mischen SyndromsHematologic Complications of Chronic Renal FailureCase Number 12 Hypertension with NephrosclerosisThe Significance of Microangiopathic Haemolytic Anaemia in Accelerated HypertensionOliguric acute renal failure in malignant hypertensionMICROANGIOPATHIC HÆMOLYTIC ANÆMIA AND THE PATHOGENESIS OF MALIGNANT HYPERTENSIONMicroangiopathic Hemolytic Anemia in Carcinoma of the Stomach 1 January 1966Volume 64, Issue 1Page: 128-136KeywordsAnemiaAttentionErythropoiesisHormonesHospital medicineHypertensionRenal failure ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...