Regulation of Kv4.3 Current by KChIP2 Splice Variants

Abstract

A family of KChIP2 proteins is expressed in human hearts that exhibits differential modulation of hKv4.3 current in a Ca2+-dependent fashion. The effect of KChIP2 on the biophysical properties of expressed Kv4.3 current and the absence of a gradient of protein across the ventricular wall suggest that KChIP2 is either not a requisite component of human or canine ventricular I(to) or that its functional effect is being affected or additionally modified by other factors present in myocardial cells.