Effect of cisapride on nocturnal transient lower oesophageal sphincter relaxations and nocturnal gastro‐oesophageal reflux in patients with oesophagitis: a double‐blind, placebo‐controlled study

Abstract

In patients with gastro-oesophageal reflux disease, cisapride significantly decreased the frequency of transient lower oesophageal sphincter relaxations during sleep and increased lower oesophageal sphincter pressure without changing gastric emptying. We hypothesize, therefore, that 5-hydroxytryptamine-4 mechanisms are important in the control of transient lower oesophageal sphincter relaxations in humans.