Synthesis of<i>N</i>-(Diisopropyloxyphosphoryl)amino Acids and Peptides

Abstract

N-(Diisopropyloxyphosphoryl)amino acids (N-Dipp-amino acids) are prepared from diisopropyl phosphite and amino acids in mixed aqueous media in one step. They can be activated by dicyclohexylcarbodiimide or other activating agents for the synthesis of N-(diisopropyloxyphosphoryl)dipeptides.