Implications of mismatch repair genes h <i>MLH1</i> and h <i>MSH2</i> in patients with sporadic renal cell carcinoma

Abstract

Our data show that loss of function of both hMLH1 and hMSH2 is not involved in sporadic RCC, either by promoter methylation or mutation in their exons. However, LOH indicated that chromosomal instability affecting large fragments of DNA was the main genetic alteration we detected associated with RCC.