Concepedia

A CONVENIENT SYNTHESIS OF 4-TRICHLOROMETHYL-PYRIMIDIN-2-YLAMINE DERIVATIVES

Nilo Zanatta, Iraci de Lourdes Pacholski, Débora Faoro, Hélio G. Bonacorso, Marcos A. P. Martins

Synthetic Communications · 2001 · 17 citations · 17 references

DOI

Concepts

Abstract

A convenient method for the synthesis of a series of 4-trichloromethyl-pyrimidin-2-ylamines from the reaction of 4-trichloromethyl-2-chloropyrimidine and ammonium hydroxide, primary- and secondary-amines, and guanidine hydrochloride, is reported. This reactions was also extended to obtain 4-trichloromethyl-2-alkoxy-pyrimidines.

References

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