Intraepithelial lymphocytes and coeliac disease: permanent changes in CD3⁻/CD7⁺ and T cell receptor γβ subsets studied by flow cytometry

Abstract

Changes in T cell receptor gammadelta and CD3-/CD7+ intraepithelial lymphocytes subsets are permanently observed in paediatric coeliac disease. Their assessment, by three-colour flow cytometry on routine diagnostic biopsies, permits a better characterization of coeliac enteropathy and represents a valuable procedure to identify coeliac patients with different clinical presentations.