Coombs'-positive Hemolytic Anemia in Hodgkin's Disease

Abstract

Article1 February 1967Coombs'-positive Hemolytic Anemia in Hodgkin's DiseaseERIC EISNER, M.D., ALLYN B. LEY, M.D., KLAUS MAYER, M.D., F.A.C.P.ERIC EISNER, M.D.Search for more papers by this author, ALLYN B. LEY, M.D.Search for more papers by this author, KLAUS MAYER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-2-258 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnemia, more or less severe in intensity, occurs in the course of nearly all cases of Hodgkin's disease. Although the dominant defect is usually one of insufficient red cell production, a decreased erythrocyte life-span has been demonstrated in a number of studies (1-5); indeed, a recent report (6) suggests that a significantly shortened red cell survival is characteristic of the advanced stages of the disease. The mechanism of this increased rate of cell destruction is not known. The classical manifestations of hemolytic anemia are scant or absent. Evidences of markedly increased hemoglobin catabolism and of intense erythropoiesis are usually not...References1. BROWN GM: Pathogenesis of secondary anaemias. Canad. Med. Ass. J. 62: 472, 1950. MedlineGoogle Scholar2. HYMAN GA: Studies on anemia of disseminated malignant neoplastic disease. I. Hemolytic factor. Blood 9: 911, 1954. CrossrefMedlineGoogle Scholar3. VERLOOP MC: Anaemia in systemic diseases. Acta Med. Scand. 151: 367, 1955. CrossrefMedlineGoogle Scholar4. GIANNOPOULOSBERGSAGEL PPDE: The mechanism of anemia associated with Hodgkin's disease. Blood 14: 856, 1959. CrossrefMedlineGoogle Scholar5. DESFORGESROSSMOLONEY JFJDWC: Mechanisms of anemia in leukemia and malignant lymphoma. Amer. J. Med. 28: 69, 1960. CrossrefMedlineGoogle Scholar6. CLINEBERLIN MJNI: Anemia in Hodgkin's disease. Cancer 16: 526, 1963. 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Y.This study was supported in part by grants CA-03809-07 and CA-08748, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Allyn B. Ley, M.D., The New York Hospital-Cornell Medical Center, 525 E. 68th St., New York, N. Y. 10021. 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