Concepedia

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

Wei Xiang, Johannes C. M. Schlachetzki, Stefan Helling, Julia Bussmann, Marvin Berlinghof, Tilman E. Schäffer, Katrin Marcus, Jürgen Winkler, Jochen Klucken, Cord‐Michael Becker

Molecular and Cellular Neuroscience · 2013 · 153 citations · 39 references

DOI

Concepts

References

39

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Kelvin C. Luk, Victoria Kehm, Jenna C. Carroll et al. · Science · 2012 · 2.6K citations

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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

W. Sean Davidson, Ana Jonas, David F. Clayton et al. · Journal of Biological Chemistry · 1998 · 1.6K citations · Full text

, , +17

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Benoit I. Giasson, John E. Duda, Ian Murray et al. · Science · 2000 · 1.5K citations

, , +16

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

Paul H. Weinreb, Weiguo Zhen, Anna W. Poon et al. · Biochemistry · 1996 · 1.5K citations

, , +17

In vivo demonstration that α-synuclein oligomers are toxic

Beate Winner, Roberto Jappelli, Samir K. Maji et al. · Proceedings of the National Academy of Sciences · 2011 · 1.5K citations · Full text

, , +17