Hypoglycaemic activity of <i>Nelumbo nucifera</i> gaertn. (Fam. Nymphaeaceae) rhizome (methanolic extract) in streptozotocin‐induced diabetic rats

Abstract

Abstract The hypoglycaemic effect of the rhizome extract of Nelumbo nucifera was studied in streptozotocin‐induced diabetic rats. A methanol extract of the plant obtained by soxhlet extraction from finely pulverized rhizomes was used. The LD 50 of the extract was found to be 2 g/kg. The extract (300 mg/kg and 600 mg/kg, orally) caused a reduction of blood glucose levels in streptozotocin‐induced diabetic rats by 53% ( p &lt;0.001) and 55% ( p &lt;0.001) respectively at the end of 12 h. The results of this study indicate that the methanol extract of the rhizome possesses favourable hypoglycaemic activity in hyperglycaemic animals taking chlorpropamide as a standard.