Concepedia

Highly Selective Amidation of Benzylic Alcohols with Nitriles. A Modified Ritter Reaction

H. Firouzabadi, Ali Reza Sardarian, Hassan Badparva

Synthetic Communications · 1994 · 54 citations · 6 references

DOI

Concepts

Abstract

Abstract Benzyl alcohols react selectively with different nitriles in the presence of a catalytic amount of boron trifluoride and produce amides in high yields. Deactivated p-nitrobenzyl, allylic, primary, secondary, and tertiary saturated alcohols do not react.

References

6

N-Alkylation of nitriles using chromium tricarbonyl complexes of benzyl alcohol and its derivatives: new perspectives for the Ritter reaction

Siden Top, Gérard Jaouen · The Journal of Organic Chemistry · 1981 · 99 citations

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A New Reaction of Nitriles. III. Amides from Dinitriles

Frederic R. Benson, John J. Ritter · Journal of the American Chemical Society · 1949 · 95 citations

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An improved modification of ritter reaction

A García Martínez, Roberto Martínez Álvarez, Enrique Teso Vilar et al. · Tetrahedron Letters · 1989 · 80 citations

, , +1

Organic Reactions with Boron Fluoride.<sup>1</sup> XVII

James F. McKenna, Frank Sowa · Journal of the American Chemical Society · 1938 · 27 citations

, , +7

Conversion of alcohols into amides by chlorodiphenylmethylium hexachloroantimonate in nitrile solvents; some further reactions of the triphenylmethyl cation

D. H. R. BARTON, Philip Magnus, Juan A. Garbarino et al. · Journal of the Chemical Society Perkin Transactions 1 · 1974 · 26 citations

, , +5