Transgenic Expression of Cytotoxic T-Lymphocyte-Associated Antigen 4-Immunoglobulin Prolongs Xenogeneic Skin Graft Survival Without Extensive Immunosuppression in Rat Burn Wounds

Abstract

transgenic expression of CTLA4Ig may be a potential and safe method to prolong xenogenic skin graft survival in burn wounds, and transgenic animal lines can be established as a reproducible source of skin grafts with extended survival for wound coverage.