Quantitative Topographical Electroencephalographic Analysis After Intravenous Clonidine in Healthy Male Volunteers

Abstract

In healthy volunteers, placebo-controlled signal changes in the electroencephalogram were evaluated to quantify sedative drug effects after intravenous application of clonidine. A multichannel recording system and electroencephalogram mapping technique indicate fluctuations of electroencephalogram patterns that are not homogeneously distributed over the cortex associated with sedation.