Acute Necrotizing Eosinophilic Myocarditis as a Manifestation of Severe Hypersensitivity Myocarditis

Abstract

Brief Report1 August 1991Acute Necrotizing Eosinophilic Myocarditis as a Manifestation of Severe Hypersensitivity MyocarditisAntemortem Diagnosis and Successful TreatmentMark A. Getz, MD, Ramiah Subramanian, MD, Tim Logemann, MD, Ford Ballantyne, MDMark A. Getz, MD, Ramiah Subramanian, MD, Tim Logemann, MD, Ford Ballantyne, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-3-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute necrotizing eosinophilic myocarditis is characterized by acute and fulminant congestive heart failure that has previously been uniformly fatal (1, 2). Predisposing factors include an initial viral infection and an underlying allergic diathesis. This disease's pathologic characteristics include eosinophilic and lymphocytic infiltration with extensive myocardial cell necrosis and no notable extracardiac pathologic findings. Hypersensitivity myocarditis is characterized by rash, fever, sinus tachycardia, and eosinophilia related to a drug allergy. This entity is also characterized by eosinophilic and lymphocytic infiltration of the myocardium, but necrosis is uncommon (3). Patients with hypersensitivity myocarditis usually are not critically ill, and they respond to...References1. Herzog C, Snover D, and Staley N. Acute necrotizing eosinophilic myocarditis. Br Heart J. 1984;52:343-8. CrossrefMedlineGoogle Scholar2. deMello D, Liapis H, Jureidini S, Nouri S, Kephart G, and Gleich G. Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis. N Engl J Med. 1990;323:1542-5. CrossrefMedlineGoogle Scholar3. Fenoglio J, McAllister H, and Mullick F. Drug related myocarditis. Hum Pathol. 1981;12:900-7. CrossrefMedlineGoogle Scholar4. Doherty N and Siegel R. Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J. 1984;110:1257-65. CrossrefGoogle Scholar5. Billingham M. Pharmacotoxic myocardial disease: an endomyocardial study. Heart Vessels (Suppl). 1985;1:278-82. CrossrefGoogle Scholar6. French A and Weller C. Interstitial myocarditis following the clinical and experimental use of sulfonamide drugs. Am J Pathol. 1942;18:109-21. MedlineGoogle Scholar7. Morrow P, Hardin N, and Bonadies J. Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. J Forensic Sci. 1989;34:1016-20. CrossrefMedlineGoogle Scholar8. Taliercio C, Olney B, and Lie J. Myocarditis related to drug hypersensitivity. Mayo Clin Proc. 1985;60:463-8. CrossrefMedlineGoogle Scholar9. Parrillo J. Heart disease and the eosinophil [Editorial]. N Engl J Med. 1990;323:1560-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mark A. Getz, MD; Ramiah Subramanian, MD; Tim Logemann, MD; Ford Ballantyne, MDFrom the University of Wisconsin Medical School and the William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin. For current author addresses, see end of text. 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