Acta Haematologica · 2009 · 26 citations · 0 references
MedicineGeneticsHematologyBiochemical GeneticsHematopathologyHuman GeneticsAnemiaClinical HematologyHematologic DisordersHemoglobin PhysiologyHemolytic DisordersRed Blood Cell DisordersHeme ProteinsHemoglobin DysfunctionHemoglobin StructureHemoglobin-oxygen AffinityOxygen Affinity RegulationOxygen Binding Affinity
A new alpha chain abnormal hemoglobin variant was found in a Turkish patient with a mild Heinz body hemolytic anemia and splenomegaly. The substitution alpha 86 Leu leads to Arg, which is next to the heme binding proximal histidine, is responsible for a marked instability of the molecule. The oxygen affinity of the erythrocytes was found to be slightly decreased.