Concepedia

Solid-Phase Synthesis of Substituted Alkynes Using the Nicholas Reaction

Johan Cassel, Stefanie Leue, Natalie I. Gachkova, Nina Kann

The Journal of Organic Chemistry · 2002 · 22 citations · 4 references

DOI

Concepts

Abstract

The first example of a Nicholas reaction on solid phase is reported, involving the reaction of cobalt complexes of polymer-bound alkynols with different nucleophiles in the presence of a Lewis acid, to form carbon-oxygen or carbon-carbon bonds.

References

4

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