Oncology · 2009 · 14 citations · 0 references
MedicineImmunologyOncologyCancer EpidemiologyCancer ImmunologyImmunogeneticsBreast Cancer Risk AssessmentCancer IncidenceCancer RiskHla TypingMalignant NeoplasmsTumor AntigensCorrelationHla Allele Frequency DistributionHla Genotype AssociationsHla Polymorphism AnalysisHla Risk AllelesMolecular Hla TypingRelative Risk EstimationTumor Incidence Analysis
HLA determinations were made at the time of diagnosis among a lot of 141 patients with breast cancer. Values of relative risk as well as frequencies of antigens at the first and the second locus were confronted to data found in a control population. Subdivisions of the neoplastic population according to hormonal status and parity led to the emergence of significant differences: frequency of A28 in menopausal nulliparous women with breast cancer is 26 vs. 7% in controls (p corrected = 0.038) with relative risk = 6.63 (p 0.001).