Intervertebral Disc Cells Produce Tumor Necrosis Factor α, Interleukin-1β, and Monocyte Chemoattractant Protein-1 Immediately After Herniation: An Experimental Study Using a New Hernia Model

Abstract

The new hernia model appears to be very useful for studying herniated disc resorption. Intervertebral disc cells may produce inflammatory cytokines/chemokine immediately after the onset of disc herniation, possibly triggering subsequent macrophage infiltration that leads to disc resorption.