Interleukins 1 beta and 6 induce functional alteration of rat colonic motility: an <i>in vitro</i> study

Abstract

Early inflammation induced by a subchronic treatment with ILs causes changes in mucosal ionic transport parameters, a reduction in the direct contractile response, and an alteration in the neurotransmission (by an enhancing cholinergic component) that may affect the physiological pattern of colonic motility and the sensory reflex.