Concepedia

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

Christina Grothusen, A Hagemann, Tim Attmann, Jan Hinrich Braesen, Ole Broch, Jochen Cremer, Jan Schoettler

The Scientific World JOURNAL · 2012 · 23 citations · 16 references

Open access

Abstract

One-time intravenous administration of Anakinra prior to myocardial reperfusion reduces infarct size in experimental ischemia/reperfusion injury. Thus, Anakinra may represent a treatment option in myocardial infarction prior to revascularization.

References

16

Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

European Heart Journal · 2010 · 3.2K citations · Full text

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

Antonio Abbate, Fadi N. Salloum, Elena Vecile et al. · Circulation · 2008 · 358 citations · Full text

Trends in Acute Coronary Heart Disease Mortality, Morbidity, and Medical Care From 1985 Through 1997

Paul G. McGovern, David R. Jacobs, Eyal Shahar et al. · Circulation · 2001 · 343 citations

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

Ignatios Ikonomidis, John Lekakis, Maria Nikolaou et al. · Circulation · 2008 · 300 citations

Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice

Faten Merhi‐Soussi, Brenda R. Kwak, David Magne et al. · Cardiovascular Research · 2005 · 195 citations · Full text