Is the fixation of observable mutations distributed randomly among the three nucleotide positions of the codon?

Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology

Walter M. Fitch · Systematic Zoology · 1971 · 5.6K citations

Life Sciences, Evolutionary Biology, Zoology +17

An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution

Walter M. Fitch, Etan Markowitz · Biochemical Genetics · 1970 · 471 citations

Life Sciences, Genetics, Molecular Genetics +14

Relations between chemical structure and biological activity in peptides

P. H. A. Sneath · Journal of Theoretical Biology · 1966 · 297 citations

Life Sciences, Biochemistry, Chemistry +14

Minimum Mutation Fits to a Given Tree

J. A. Hartigan · Biometrics · 1973 · 278 citations

Life Sciences, Biology, Evolutionary Biology +10

Amino-Acid Sequence of Horse Heart Cytochrome C : The Complete Amino-acid Sequence

E. Margoliash, Emil L. Smith, Günther Kreil et al. · Nature · 1961 · 264 citations

Life Sciences, Biochemistry, Molecular Biology +6