Flattened Cone 2,8,14,20‐Tetrakis(<scp>L</scp>‐valinamido)[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase

Abstract

A get-out clause: Displacement of the enantiomers of tryptophan from the achiral hydrophobic rim of a flattened cone resorcinarene derivative is induced by 2-aminobutane (B). The displacement exhibits a marked enantioselectivity which is traced to a conformational coupling between the achiral hydrophobic rim of the resorcinarene host and its chiral hydrophilic rim wherein the 2-aminobutane enantiomers are trapped.