Melanoma Research · 2005 · 62 citations · 31 references
MedicineDermatologyGeneticsCancer GeneticsHuman GeneticsMolecular OncologyMelanocytic LesionsMelanocytic TumorsMutation AnalysisOncogene AmplificationOncogene MutationsReceptor Tyrosine Kinase OncogenesBraf V600 MutationsDysplastic LesionsMelanocytic Neoplasm PathologyMelanocytic Tumor GeneticsMelanocytic Tumor Molecular PathologyMutational Spectrum AnalysisOncogenic Ras MutationsSingle-strand Conformation Polymorphism
Eighteen congenital melanocytic naevi (CMN) from 17 patients and 18 dysplastic melanocytic naevi (DMN) from 18 patients were screened for mutations in the BRAF oncogene (present study) and the N-ras oncogene (in the course of two foregoing studies) by single-strand conformational polymorphism (SSCP)/sequencing analysis. BRAF mutations were demonstrated in both types of lesion. As a whole, 17 of 18 CMN (94.4%) and five of 18 DMN (27.7%) harboured either BRAF or N-ras mutations. As the BRAF oncogene is frequently found to be mutated in human cutaneous melanomas, it may constitute a risk factor for melanoma formation within CMN and DMN.
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