THE INFLUENCE OF CORTISONE ON EXPERIMENTAL FUNGUS INFECTIONS IN MICE*

Abstract

Alice. Two strains of mice were used. In all studies on histoplasmosis and cryptococcosis, and in some of the Candida experiments, female Swiss albino mice, 17 to 20 g, from the National Institutes of Health (NIH) were used. Mice of this strain tolerated up to 2.0 mg cortisone per day for 28 days without weight loss or other noticeable deleterious effects, although some animals failed to gain weight during steroid administration.