The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Defective B cell development and function in Btk-deficient mice

Wasif N. Khan, Frederick W. Alt, Rachel M. Gerstein et al. · Immunity · 1995 · 727 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

Masahiro Kawabuchi, Yoshinori Satomi, Toshifumi Takao et al. · Nature · 2000 · 518 citations

Life Sciences, Biochemistry, Molecular Biology +12

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Jill K. Slack‐Davis, Karen H. Martin, Robert W. Tilghman et al. · Journal of Biological Chemistry · 2007 · 483 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +17

Action of the Src Family Kinase Inhibitor, Dasatinib (BMS-354825), on Human Prostate Cancer Cells

Sangkil Nam, Donghwa Kim, Jin Cheng et al. · Cancer Research · 2005 · 374 citations · Full text

Medicine, Oncology, Pharmacology +17