Methotrexate administered by 6-h and 24-h infusion: a pharmacokinetic comparison

Clinical pharmacokinetics; concepts and applications

General Pharmacology The Vascular System · 1989 · 2.2K citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +12

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

Bruce A. Chabner, Robert C. Young · Journal of Clinical Investigation · 1973 · 238 citations · Full text

Medicine, Oncology, Pharmacology +9

Competitive protein binding assay for methotrexate.

Charles E. Myers, Marc E. Lippman, H M Elliot et al. · Proceedings of the National Academy of Sciences · 1975 · 98 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.

H. M. Pinedo · PubMed · 1977 · 81 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.

Takao Ohnuma, Ruju Julia Lo, Kevin J. Scanlon et al. · PubMed · 1985 · 62 citations

Medicine, Oncology, Pharmacology +16