Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.6K citations

Map Interpretation, Structural Bioinformatics, Biomolecular Structure Prediction +16

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

Jung‐Won Choi, Jie Chen, Stuart L. Schreiber et al. · Science · 1996 · 920 citations

Crystal Structure, Human Frap, Molecular Physiology +15

The structural basis of the activation of Ras by Sos

P. Ann Boriack‐Sjodin, S.M. Margarit, Dafna Bar‐Sagi et al. · Nature · 1998 · 791 citations

Neuroscience, Signal Transduction, Molecular Biology +1

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

J. Bernd Helms, James E. Rothman · Nature · 1992 · 750 citations

Golgi Membrane Enzyme, Cellular Enzymology, Biochemistry +6

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

Julie G. Donaldson, Dario Finazzi, Richard D. Klausner · Nature · 1992 · 745 citations

Protein Function, Signal Transduction, Biochemistry +9