Concepedia

Publication | Closed Access

Anti-Babesial Compounds from<i>Curcuma zedoaria</i>

DOI

23

Citations

0

References

2005

Year

Ken Kasahara, Shinkichi Nomura, Subeki Subeki, Hideyuki Matsuura, Masahiro Yamasaki, Osamu Yamato, Yoshimitsu Maede, Ken Katakura, Mamoru Suzuki, Trimurningsih,
Planta Medica

Abstract

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively.