Synovial fluid mesenchymal stem cells in health and early osteoarthritis: Detection and functional evaluation at the single‐cell level

Abstract

This study confirms the presence of MSCs in normal SF and shows their numerical increase in early human OA. SF MSCs are likely to originate from synovium. These findings provide a platform for the exploration of the potential role of SF MSCs in joint homeostasis and for investigation of their utility in novel joint regeneration strategies.