Indeno[1,2‐<i>d</i>]pyrido[1,2‐<i>a</i>]pyrimidines: A New Class of Receptor Tyrosine Kinase Inhibitors

Abstract

Indanedione ketene dimer 3, obtained in quantitative yield from the thermal decomposition of the phenyliodonium ylide of 2-hydroxy-1,4-naphthoquinone, reacts readily with 2-aminopyridines and 2-aminopyrimidines to afford the title compounds. They represent a new class of cell-permeable inhibitors for receptor tyrosine kinases implicated in angiogenesis and cancer cell proliferation.