Chemical Communications · 2011 · 84 citations · 27 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanomaterialsNanoparticle Drug DeliveryDrug EncapsulationNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle DesignNanoparticle FormulationsAnticancer Drug LoadingDna NanocarriersDrug Delivery NanocarriersDrug Release MechanismsGold Nanoparticle Drug DeliveryHydrodynamic RadiusNanoparticle Delivery VectorsNanoparticles
The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.
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