Advanced Synthesis & Catalysis · 2004 · 215 citations · 44 references
Natural SciencesChemical EngineeringChemistryCatalysisIndustrial ChemistryReaction EngineeringCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic Reaction EngineeringIndustrial CatalysisIndustrial Catalytic ProcessesC - C Coupling CatalysisC - C Coupling ReactionsC-c Coupling CatalysisCatalyst Development For SynthesisCatalytic Reaction MechanismsCatalytic SynthesisMultistep SynthesisTransition Metal-catalyzed Synthesis
Abstract R&D issues for the application of Pd‐ and Ni‐catalyzed CC and CN coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of CC and CN coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi‐step syntheses.
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