Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes mellitus

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

R. A. DeFronzo, J. D. Tobin, R Andres · American Journal of Physiology-Endocrinology and Metabolism · 1979 · 7.4K citations

Priming Infusion, Artificial Pancreas, Negative Feedback Principle +18

Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function

Steven E. Kahn, Ronald L. Prigeon, David K. McCulloch et al. · Diabetes · 1993 · 1.4K citations

Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose

Muhammad Abdul-Ghani, Devjit Tripathy, Ralph A. DeFronzo · Diabetes Care · 2006 · 731 citations · Full text

Metabolic Disorder, β-Cell Dysfunction, Insulin Signaling +20

Diagnosis and Classification of Diabetes Mellitus

Diabetes Care · 2006 · 574 citations

Diabetes Management, Diabetes, Diagnosis +3

Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man

Naji N. Abumrad, David Rabin, Michael P. Diamond et al. · Metabolism · 1981 · 572 citations

Alanine Kinetics, Biochemistry, Bioanalysis +6