Concepedia

Reactions of dilithiooximes, dilithiophenylhydrazones and trilithiohydrazones with nitriles. Acid‐cyclization to isoxazoles or pyrazoles

Charles F. Beam, Robert S. Foote, Charles R. Hauser

Journal of Heterocyclic Chemistry · 1972 · 37 citations · 10 references

DOI

Concepts

Abstract

Abstract Certain C(α)O ‐dilithiooximes, C(α)N ‐dilithiophenylhydrazones, and C(α)N,N ‐trilithiohydrazones were treated with a variety of nitriles. The intermediates were not isolated, but cyclized with acid to give isoxazoles or pyrazoles.

References

10

The Systematic Identification of Organic Compounds

Nature · 1936 · 1.2K citations · Full text

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Synthesis of Simple Hydrazones of Carbonyl Compounds by an Exchange Reaction

George R. Newkome, D. L. Fishel · The Journal of Organic Chemistry · 1966 · 84 citations

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New synthesis of isoxazoles from 1,4-dianions of oximes having an .alpha. hydrogen. Mass spectrometry

Charles F. Beam, Morgan C. D. Dyer, Richard A. Schwarz et al. · The Journal of Organic Chemistry · 1970 · 67 citations

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CONDENSATIONS OF NITRILES HAVING α-HYDROGEN TO FORM β-IMINONITRILES, CYCLIC TRIMERS, AND SUBSTITUTED 2-HYDROXY-4-AMINOPYRIDINES<sup>1</sup>

G. A. Reynolds, W. J. Humphlett, Frederic W. Swamer et al. · The Journal of Organic Chemistry · 1951 · 44 citations

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A new synthesis of substituted pyrazoles from 1,4‐dianions of phenylhydrazones having an α‐hydrogen

Robert S. Foote, Charles F. Beam, Charles R. Hauser · Journal of Heterocyclic Chemistry · 1970 · 33 citations

, , +10