Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

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Glucose clamp technique: a method for quantifying insulin secretion and resistance.

R. A. DeFronzo, J. D. Tobin, R Andres · American Journal of Physiology-Endocrinology and Metabolism · 1979 · 7.5K citations

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Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

Diabetes Care · 1997 · 6.2K citations

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The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Christian Weyer, Clifton Bogardus, David M. Mott et al. · Journal of Clinical Investigation · 1999 · 2K citations · Full text

Medicine, Endocrinology, Physiology +11

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

Eve Van Cauter, Fabienne Mestrez, Jeppe Sturis et al. · Diabetes · 1992 · 813 citations

Pharmacy, Endocrinology, Physiology +15