The Plasticizer Di(2-ethylhexyl) Phthalate Modulates γ-Aminobutyric Acid Type A and Glycine Receptor Function

Abstract

The plasticizer DEHP modulates the function of both GABA(A) and glycine receptors. DEHP contamination can confound the results of electrophysiologic studies of anesthetic mechanisms on these receptors if DEHP-plasticized PVC is present in the experimental apparatus.