Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin–angiotensin–aldosterone‐system

Abstract

At the present arterial plasma concentrations, AngIII is equipotent to AngII with regard to effects on blood pressure, aldosterone secretion and renal functions, and these AngIII effects are mediated through AT1- receptors. The metabolic clearance rate of AngIII is five times that of AngII.