Publication | Closed Access
Total Syntheses of Antimycin A3 and Its Diastereomer
52
Citations
8
References
1973
Year
BiosynthesisBioorganic ChemistryAbsolute ConfigurationEngineeringOrganic ChemistryDilactone MoietiesHeterocycle ChemistryStereoselective SynthesisPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringAntimycin A3Natural Product Synthesis
Abstract Natural antimycin A3 (1A) and its diastereomer (1B) were synthesized. By the syntheses, the correlations between configurations of the enantiomeric 2-butyl-4-hydroxy-3-isovaleryloxypentanoic acids present in the dilactone moieties of 1A and 1B, and those of natural (+)blastmycinone (+)7a and its enantiomer (−)7a were confirmed. The absolute configuration of 1B was also determined.
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