Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room Temperature <i>Without</i> Prior Formation of Organozinc Reagents

Abstract

Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.