Mitomycin-C Induces the Apoptosis of Human Tenon’s Capsule Fibroblast by Activation of<i>c-Jun</i>N-Terminal Kinase 1 and Caspase-3 Protease

Abstract

Mitomycin-C induced the apoptosis of HTCFs through the activation of intrinsic and extrinsic caspase cascades with mitochondrial dysfunction. It also activated Fas-mediated apoptotic signaling of fibroblasts. Furthermore, the activation of JNK1 played a major role in the cytotoxicity of mitomycin-C.