Enantioselective Synthesis with Optically Active Transition-Metal Catalysts

Abstract

This review attempts a complete survey of all the recently published organic syntheses in which optically active transition-metal compounds have been used as enantioselective catalysts in substoichiometric amounts. 1. Introduction 2. Reduction 2.1. Hydrogenation of Didehydroamino Acids 2.2. Hydrogenation of Other Olefins 2.3. Hydrogenation of Ketones and Imines 2.4. Transfer Hydrogenation 2.5. Hydrosilylation 3. Oxidation 3.1. Epoxidation 3.2. Sulfide Oxidation 4. C-C Bond Formation 4.1. Hydroformylation 4.2. Grignard Cross-Coupling 4.3. Allylic Alkylation 4.4. Cyclopropanation 4.5. Diels-Alder Reaction 4.6. Aldol Reaction 4.7. Hydrocyanation 4.8. Cylization of Unsaturated Aldehydes 4.9. Polymerization 5. Other Reactions