Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine Neoplasia

Abstract

Our results support the previous finding that germline CDKN1B/p27(Kip1) mutations predispose to a human MEN1-like condition. However, such mutations appear uncommon in suspected MEN1 cases and rare or nonexistent in familial or sporadic acromegaly/pituitary adenoma patients.