Vascularized Thymic Lobe Transplantation in a Pig-to-Baboon Model: A Novel Strategy for Xenogeneic Tolerance Induction and T-cell Reconstitution

Abstract

VTL transplantation from hDAF swine to baboons induced early thymopoiesis in the recipients and donor-specific cellular unresponsiveness in vitro. When coupled with additional strategies aimed at silencing humoral rejection, VTL transplantation may significantly prolong xenograft survival and result in long-term tolerance.